Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway

Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway

Background & Aims: Infection is a major problem in advanced liver disease secondary to monocyte dysfunction. Elevated prostaglandin (PG)E2 is a mediator of monocyte dysfunction in cirrhosis; thus, we examined PGE2 signalling in outpatients with ascites and in patients hospitalised with acute...

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Bibliographic Details
Main Authors: Alexander A. Maini, Natalia Becares, Louise China, Thais H. Tittanegro, Amit Patel, Roel P.H. De Maeyer, Nekisa Zakeri, Tu Vinh Long, Lucy Ly, Derek W. Gilroy, Alastair O’Brien
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:JHEP Reports
Subjects:
HLA-DR
TNF
IL6
LPS
Cyclo-oxygenase 1
Microsomal PGE synthase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921001087

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http://www.sciencedirect.com/science/article/pii/S2589555921001087

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