Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair

Hypoxia preconditioning of adipose stem cell-derived exosomes loaded in gelatin methacryloyl (GelMA) promote type H angiogenesis and osteoporotic fracture repair

Abstract The challenges posed by delayed atrophic healing and nonunion stand as formidable obstacles in osteoporotic fracture treatment. The processes of type H angiogenesis and osteogenesis emerge as pivotal mechanisms during bone regeneration. Notably, the preconditioning of adipose-derived stem c...

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Bibliographic Details
Main Authors: Xiaoqun Li, Shuo Fang, Shaohai Wang, Yang Xie, Yan Xia, Panfeng Wang, Zichen Hao, Shuogui Xu, Yuntong Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Nanobiotechnology
Subjects:
Hypo-ADSC-Exos
miR-21-5p
Angiogenesis
GelMA
Type H vessels
Osteoporotic fracture repair
Online Access:https://doi.org/10.1186/s12951-024-02342-6

Internet

https://doi.org/10.1186/s12951-024-02342-6

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