A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge

A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge

Abstract Influenza virosomes serve as antigen delivery vehicles and pre-existing immunity toward influenza improves the immune responses toward antigens. Here, vaccine efficacy was evaluated in non-human primates with a COVID-19 virosome-based vaccine containing a low dose of RBD protein (15 µg) and...

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Bibliographic Details
Main Authors: Gerrit Koopman, Mario Amacker, Toon Stegmann, Ernst J. Verschoor, Babs E. Verstrepen, Farien Bhoelan, Denzel Bemelman, Kinga P. Böszörményi, Zahra Fagrouch, Gwendoline Kiemenyi-Kayere, Daniella Mortier, Dagmar E. Verel, Henk Niphuis, Roja Fidel Acar, Ivanela Kondova, Yolanda S. Kap, Willy M. J. M. Bogers, Petra Mooij, Sylvain Fleury
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-31818-y

Internet

https://doi.org/10.1038/s41598-023-31818-y

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