Treatment response of advanced HNSCC towards immune checkpoint inhibition is associated with an activated effector memory T cell phenotype

Treatment response of advanced HNSCC towards immune checkpoint inhibition is associated with an activated effector memory T cell phenotype

Locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with a poor prognosis. The introduction of PD-1 inhibitors has led to a significant improvement in survival, but only a subpopulation of patients responds to therapy. Current biomarkers cannot reliably identif...

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Bibliographic Details
Main Authors: Max Schumacher, Sina Beer, Emmanuelle Moraes Ribeiro, Fulya Korkmaz, Hildegard Keppeler, Rahel Fitzel, Estelle Erkner, Pia Radszuweit, Claudia Lengerke, Corina Schneidawind, Sebastian Hoefert, Paul Stefan Mauz, Dominik Schneidawind
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Oncology
Subjects:
PD-1
HNSCC
immune checkpoint inhibition
peripheral T cells
predictive biomarker
activation marker
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1333640/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1333640/full

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