Predicting cognitive dysfunction and regional hubs using Braak staging amyloid-beta biomarkers and machine learning

Predicting cognitive dysfunction and regional hubs using Braak staging amyloid-beta biomarkers and machine learning

Abstract Mild cognitive impairment (MCI) is a transitional stage between normal aging and early Alzheimer’s disease (AD). The presence of extracellular amyloid-beta (Aβ) in Braak regions suggests a connection with cognitive dysfunction in MCI/AD. Investigating the multivariate predictive relationshi...

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Bibliographic Details
Main Authors: Puskar Bhattarai, Ahmed Taha, Bhavin Soni, Deepa S. Thakuri, Erin Ritter, Ganesh B. Chand
Format: Article
Language:English
Published: SpringerOpen 2023-12-01
Series:Brain Informatics
Subjects:
Mild cognitive impairment
Machine learning
Amyloid-beta
Feature importance
Braak staging
Neuroimaging
Online Access:https://doi.org/10.1186/s40708-023-00213-8

Internet

https://doi.org/10.1186/s40708-023-00213-8

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