Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake

Optimization of a Cefuroxime Axetil-Loaded Liquid Self-Nanoemulsifying Drug Delivery System: Enhanced Solubility, Dissolution and Caco-2 Cell Uptake

Cefuroxime axetil (CA) is an oral cephalosporin which hydrolyzes rapidly to the active parent compound cefuroxime. CA is known to have incomplete oral bioavailability (30–50%) due to its poor solubility and enzymatic conversion to cefuroxime in the gut lumen. In order to overcome these drawbacks, a...

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Bibliographic Details
Main Authors: Arshad Ali Khan, Akhtar Atiya, Safia Akhtar, Yogesh Yadav, Kamal A. Qureshi, Mariusz Jaremko, Syed Mahmood
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
cefuroxime axetil
pseudo-ternary phase diagrams
self-nanoemulsifying drug delivery system
Caco-2 cells
cytotoxicity
cellular uptake
Online Access:https://www.mdpi.com/1999-4923/14/4/772

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https://www.mdpi.com/1999-4923/14/4/772

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