Higher Cytokine and Opsonizing Antibody Production Induced by Bovine Serum Albumin (BSA)-Conjugated Tetrasaccharide Related to Streptococcus pneumoniae Type 3 Capsular Polysaccharide

Higher Cytokine and Opsonizing Antibody Production Induced by Bovine Serum Albumin (BSA)-Conjugated Tetrasaccharide Related to Streptococcus pneumoniae Type 3 Capsular Polysaccharide

A number of studies have demonstrated the limited efficacy of S. pneumoniae type 3 capsular polysaccharide (CP) in the 13-valent pneumococcal conjugate vaccine against serotype 3 invasive pneumococcal diseases and carriage. Synthetic oligosaccharides (OSs) may provide an alternative to CPs for devel...

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Bibliographic Details
Main Authors: Ekaterina A. Kurbatova, Nelli K. Akhmatova, Anton E. Zaytsev, Elina A. Akhmatova, Nadezhda B. Egorova, Natalya E. Yastrebova, Elena V. Sukhova, Dmitriy V. Yashunsky, Yury E. Tsvetkov, Nikolay E. Nifantiev
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae type 3
synthetic oligosaccharide
biotinylated oligosaccharide
conjugated oligosaccharide
antigen-binding capacity
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.578019/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.578019/full

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