BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 deadenylase and to control cell proliferation.

Detalles Bibliográficos
Autores principales: Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion
Formato: Artículo
Lenguaje:English
Publicado: Nature Portfolio 2016-02-01
Colección:Nature Communications
Acceso en línea:https://doi.org/10.1038/ncomms10811

Internet

https://doi.org/10.1038/ncomms10811

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