Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implic...

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Bibliographic Details
Main Authors: Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnan, Staffan Holmberg-Thydén, Annie Borch, Kathrine Valentini Jensen, Govardhan Anande, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Marianne Bach Treppendahl, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Nicola Ternette, Anders Gorm Pedersen, Aron Charles Eklund, John Pimanda, Kirsten Grønbæk, Sine Reker Hadrup
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19464-8

Internet

https://doi.org/10.1038/s41467-020-19464-8

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