First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation

The introduction of selenium (Se) into organic scaffolds has been demonstrated to be a promising framework in the field of medicinal chemistry. A novel design of nonsteroidal anti-inflammatory drug (NSAID) derivatives based on a bioisosteric replacement via the incorporation of Se as diacyl diseleni...

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Bibliographic Details
Main Authors: Sandra Ramos-Inza, Cesar Aliaga, Ignacio Encío, Asif Raza, Arun K. Sharma, Carlos Aydillo, Nuria Martínez-Sáez, Carmen Sanmartín, Daniel Plano
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/12/9/1666