A new mathematical model for the interpretation of translational research evaluating six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon.

A new mathematical model for the interpretation of translational research evaluating six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon.

Adjuvant therapy of stage IIB/III melanoma with interferon reduces relapse and mortality by up to 33% but is accompanied by toxicity-related complications. Polymorphisms of the CTLA-4 gene associated with autoimmune diseases could help in identifying interferon treatment benefits. We previously geno...

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Bibliographic Details
Main Authors: Petr Pancoska, John M Kirkwood, Spyros Bouros, Maria Spyropoulou-Vlachou, Eirini Pectasides, Dimosthenis Tsoutsos, Aristidis Polyzos, Christos Markopoulos, Petros Panagiotou, Ourania Castana, Dimitrios Bafaloukos, George Fountzilas, Helen Gogas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903519?pdf=render

Internet

http://europepmc.org/articles/PMC3903519?pdf=render

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