Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn

Riluzole (2-amino-6-(trifluoromethoxy)benzothiazole) is a drug known for its inhibitory effect on glutamatergic transmission and its anti-nociceptive and anti-allodynic effects in neuropathic pain rat models. Riluzole also has an enhancing effect on GABAergic synaptic transmission. However, the effe...

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Bibliographic Details
Main Authors: Ryo Taiji, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Shunji Tsutsui, Terumasa Nakatsuka, Hiroshi Yamada
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Spinal dorsal horn
Nociceptive transmission
Riluzole
Mechanical allodynia
Neuropathic pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002247

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http://www.sciencedirect.com/science/article/pii/S2405580821002247

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