Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant <i>Mycobacterium tuberculosis</i> Strains

Benzothiadiazinone-1,1-Dioxide Carbonic Anhydrase Inhibitors Suppress the Growth of Drug-Resistant <i>Mycobacterium tuberculosis</i> Strains

2<i>H</i>-Benzo[e][1,2,4]thiadiazin-3(4<i>H</i>)-one 1,1-dioxide (BTD) based carbonic anhydrase (CA) inhibitors are here explored as new anti-mycobacterial agents. The chemical features of BTD derivatives meet the criteria for a potent inhibition of β-class CA isozymes. BTD d...

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Bibliographic Details
Main Authors: Silvia Bua, Alessandro Bonardi, Georgiana Ramona Mük, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Mycobacterium</i>
drug resistance
carbonic anhydrase
inhibitors
molecular modelling
Online Access:https://www.mdpi.com/1422-0067/25/5/2584

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https://www.mdpi.com/1422-0067/25/5/2584

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