Semi-supervised integration of single-cell transcriptomics data

Abstract Batch effects in single-cell RNA-seq data pose a significant challenge for comparative analyses across samples, individuals, and conditions. Although batch effect correction methods are routinely applied, data integration often leads to overcorrection and can result in the loss of biologica...

Full description

Bibliographic Details
Main Authors: Massimo Andreatta, Léonard Hérault, Paul Gueguen, David Gfeller, Ariel J. Berenstein, Santiago J. Carmona
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45240-z