Structural and biological characterization of shortened derivatives of the cathelicidin PMAP-36

Abstract Cathelicidins, a family of host defence peptides in vertebrates, play an important role in the innate immune response, exhibiting antimicrobial activity against many bacteria, as well as viruses and fungi. This work describes the design and synthesis of shortened analogues of porcine cathel...

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Bibliographic Details
Main Authors: Barbara Biondi, Luigi de Pascale, Mario Mardirossian, Adriana Di Stasi, Matteo Favaro, Marco Scocchi, Cristina Peggion
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41945-1