Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells

Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells

Pulmonary permeability edema is characterized by reduced alveolar Na+ uptake capacity and capillary barrier dysfunction and is a potentially lethal complication of listeriosis. Apical Na+ uptake is mainly mediated by the epithelial sodium channel (ENaC) and initiates alveolar liquid clearance. Here...

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Bibliographic Details
Main Authors: Guang Yang, Helena Pillich, Richard White, Istvan Czikora, Isabelle Pochic, Qiang Yue, Martina Hudel, Boris Gorshkov, Alexander Verin, Supriya Sridhar, Carlos M. Isales, Douglas C. Eaton, Jürg Hamacher, Trinad Chakraborty, Rudolf Lucas
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
listeriolysin O
TNF
pulmonary permeability edema
epithelial sodium channel
protein kinase C-α
Online Access:http://www.mdpi.com/2072-6651/10/2/79

Internet

http://www.mdpi.com/2072-6651/10/2/79

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