Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody

In amyotrophic lateral sclerosis (ALS) and animal models of ALS, including SOD1-G93A mice, disassembly of the neuromuscular synapse precedes motor neuron loss and is sufficient to cause a decline in motor function that culminates in lethal respiratory paralysis. We treated SOD1-G93A mice with an ago...

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Bibliographic Details
Main Authors: Sarah Cantor, Wei Zhang, Nicolas Delestrée, Leonor Remédio, George Z Mentis, Steven J Burden
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
amyotrophic lateral sclerosis
neuromuscular disease
neurodegeneration
motor neuron
agonist antibody
MuSK
Online Access:https://elifesciences.org/articles/34375

Internet

https://elifesciences.org/articles/34375

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