<i>Hypericum perforatum</i> L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats

<i>Hypericum perforatum</i> L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Apoptosis in Adult Rats

Cisplatin (Cis) is a potent chemotherapeutic agent; however, it is linked with oxidative stress, inflammation, and apoptosis, which may harmfully affect the brain. <i>Hypericum perforatum</i> L. (HP L.) is a strong medicinal plant, but its hydrophobic polyphenolic compounds limit its act...

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Bibliographic Details
Main Authors: Heba M. A. Khalil, Hanan M. A. El Henafy, Islam A. Khalil, Alaa F. Bakr, Mohamed I. Fahmy, Nancy S. Younis, Riham A. El-Shiekh
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Toxics
Subjects:
cisplatin
<i>Hypericum perforatum</i> L.
neuroprotective
oxidative stress
inflammation
apoptosis
Online Access:https://www.mdpi.com/2305-6304/11/2/159

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https://www.mdpi.com/2305-6304/11/2/159

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