Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice

Objectives: This study aimed to investigate the effect of the gasdermin D (GSDMD) and mixed lineage kinase domain-like pseudokinase (MLKL) inhibitor, necrosulfonamide (NSA), on lipopolysaccharide (LPS)-induced hyperalgesia in mice. Methods: Reaction time to a thermal stimulus within...

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Bibliographic Details
Main Authors: Beyza Ozgen, Sefika Pinar Senol, Dilsah Ezgi Yilmaz, Meryem Temiz-Resitoglu, Omer Bahceli, Bahar Tunctan
Format: Article
Language:English
Published: Pensoft Publishers 2023-11-01
Series:Pharmacia
Online Access:https://pharmacia.pensoft.net/article/108995/download/pdf/