Clofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression

Clofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression

Purpose: Clofarabine, a purine nucleoside analogue and inhibitor of Ribonucleotide Reductase (RR), is used for treatment of leukemia. Clofarabine-induced defect in DNA replication, induces p53 and subsequently P53R2 genes as subunit of RR. clofarabine deregulated P53R2 gene expression leading to the...

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Bibliographic Details
Main Authors: Mohammad Rahmati-Yamchi, Nosratollah Zarghami, Hojjatollah Nozad Charoudeh, Yasin Ahmadi, Behzad Baradaran, Mohammad Khalaj-Kondori, Morteza Milani, Abolfazl Akbarzadeh, Maghsud Shaker, Mohammad Pourhassan-Moghaddam
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2015-11-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Apoptosis
Breast Cancer
DNA damage
P53R2
Online Access:http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-471.pdf

Internet

http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-471.pdf

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