Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Heterogeneity of therapeutic Monoclonal antibody (mAb) drugs are due to protein variants generated during the manufacturing process. These protein variants can be critical quality attributes (CQAs) depending on their potential impact on drug safety and/or efficacy. To identify CQAs and ensure the dr...

Full description

Bibliographic Details
Main Authors: Y. Diana Liu, Lance Cadang, Karenna Bol, Xiao Pan, Katherine Tschudi, Mansour Jazayri, Julien Camperi, David Michels, John Stults, Reed J. Harris, Feng Yang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Bioengineering
Subjects:
biotherapeutics
antibody
charge variant
Online Access:https://www.mdpi.com/2306-5354/9/11/641

Internet

https://www.mdpi.com/2306-5354/9/11/641

Similar Items