Impact of ERCC1, XPF and DNA Polymerase β Expression on Platinum Response in Patient-Derived Ovarian Cancer Xenografts

Impact of ERCC1, XPF and DNA Polymerase β Expression on Platinum Response in Patient-Derived Ovarian Cancer Xenografts

Platinum resistance is an unmet medical need in ovarian carcinoma. Molecular biomarkers to predict the response to platinum-based therapy could allow patient stratification and alternative therapeutic strategies early in clinical management. Sensitivity and resistance to platinum therapy are partial...

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Bibliographic Details
Main Authors: Federica Guffanti, Maria Francesca Alvisi, Elisa Caiola, Francesca Ricci, Marcella De Maglie, Sabina Soldati, Monica Ganzinelli, Alessandra Decio, Raffaella Giavazzi, Eliana Rulli, Giovanna Damia
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
ovarian carcinoma
patient-derived xenografts
cisplatin
nucleotide excision repair
base excision repair
biomarkers
Online Access:https://www.mdpi.com/2072-6694/12/9/2398

Internet

https://www.mdpi.com/2072-6694/12/9/2398

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