Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Abstract Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether and how the gut flora is involved in C5a...

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Bibliographic Details
Main Authors: Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji, Xueqin Li, Na Sun, Rongqing Li, Yuzhang Wu, Kuiyang Zheng, Yuchen Pan, Tingting Zhao, Jing Yang
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06500-4

Internet

https://doi.org/10.1038/s41419-024-06500-4

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