Tau seeding activity in various regions of down syndrome brain assessed by two novel assays

Tau seeding activity in various regions of down syndrome brain assessed by two novel assays

Abstract Propagation of tau pathology via the seeding of naive tau aggregation underlies the progression of Alzheimer’s disease (AD) and related tauopathies. Individuals with Down syndrome (DS) develop tau pathology at the fourth decade of life, but tau seeding activity in DS brain has not yet been...

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Bibliographic Details
Main Authors: Nana Jin, Jianlan Gu, Ruozhen Wu, Dandan Chu, Yunn Chyn Tung, Jerzy Wegiel, Thomas Wisniewski, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Acta Neuropathologica Communications
Subjects:
Down syndrome
Tau
Seeding activity
Phosphorylation
Online Access:https://doi.org/10.1186/s40478-022-01436-2

Internet

https://doi.org/10.1186/s40478-022-01436-2

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