Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

Summary: Background: Nasopharyngeal carcinoma (NPC) exhibits significant familial aggregation; however, its susceptibility genes are largely unknown. Thus, this study aimed to identify germline mutations that might contribute to the risk of familial NPC, and explore their biological functions. Meth...

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Bibliographic Details
Main Authors: Ruo-Wen Xiao, Fang Wang, Tong-Min Wang, Jiang-Bo Zhang, Zi-Yi Wu, Chang-Mi Deng, Ying Liao, Ting Zhou, Da-Wei Yang, Si-Qi Dong, Wen-Qiong Xue, Yong-Qiao He, Xiao-Hui Zheng, Xi-Zhao Li, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Yu-Ying Liu, Yun-Fei Xia, Song Gao, Jian-Bing Mu, Lin Feng, Wei-Hua Jia
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:EBioMedicine
Subjects:
Familial nasopharyngeal carcinoma
Whole-exome sequencing
POLN gene
Rare germline mutations
Epstein-Barr virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422004492

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http://www.sciencedirect.com/science/article/pii/S2352396422004492

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