Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms

Redirecting CD8 T cell immunity with self/tumor-specific affinity-matured T cell receptors (TCRs) is a promising approach for clinical adoptive T cell therapy, with the aim to improve treatment efficacy. Despite numerous functional-based studies, little is known about the characteristics of TCR sign...

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Bibliographic Details
Main Authors: Danilo Presotto, Efe Erdes, Minh Ngoc Duong, Mathilde Allard, Pierre-Olivier Regamey, Manfredo Quadroni, Marie-Agnès Doucey, Nathalie Rufer, Michael Hebeisen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
NY-ESO-1 antigen
T cell receptor engineering
T cell receptor-peptide-major histocompatibility complex affinity
hyporesponsiveness
CD3ζ
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01564/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01564/full

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