Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Improved oral bioavailability of poorly water-soluble vorinostat by self-microemulsifying drug delivery system

Abstract Background Vorinostat is a histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) with anticancer properties. However, it is plagued by low water solubility, low permeability (BCS class IV drug), and suboptimal pharmacokinetics. The purpose of the present study was to develop...

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Bibliographic Details
Main Authors: Ashok Kumar Janakiraman, Tahani Islam, Kai Bin Liew, Manogaran Elumalai, J. C. Hanish Singh
Format: Article
Language:English
Published: SpringerOpen 2022-08-01
Series:Beni-Suef University Journal of Basic and Applied Sciences
Subjects:
Vorinostat
Self-microemulsion
Surfactant
Interface
In vivo pharmacokinetic study
Oral bioavailability
Online Access:https://doi.org/10.1186/s43088-022-00279-z

Internet

https://doi.org/10.1186/s43088-022-00279-z

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