BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

Abstract HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing agents (LRAs) in the presence of antiretroviral drugs...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Jin Gohda, Kazuo Suzuki, Kai Liu, Xialin Xie, Hiroaki Takeuchi, Jun-ichiro Inoue, Yasushi Kawaguchi, Takaomi Ishida
Format: Artykuł
Język:English
Wydane: Nature Portfolio 2018-02-01
Seria:Scientific Reports
Dostęp online:https://doi.org/10.1038/s41598-018-21942-5

Internet

https://doi.org/10.1038/s41598-018-21942-5

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