β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis

β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis

The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. In the past, treatment of arthritic B cells with a β2-adrenergic receptor (β2-ADR) agonist has been shown to attenuate arthritis. In this study, the expression and sig...

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Bibliographic Details
Main Authors: Nadine Honke, Clemens J. Wiest, Georg Pongratz
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
B cells
rheumatoid arthritis
IL-10
β2-adrenergic receptors
autoimmune disease
CIA mouse model
Online Access:https://www.mdpi.com/2227-9059/10/8/1950

Internet

https://www.mdpi.com/2227-9059/10/8/1950

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