Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study

Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study

A fair number of epidemiological studies suggest that age at menarche (AAM) is associated with depression, but the reported effect sizes are small, and there is evidence of residual confounding. Moreover, previous Mendelian randomization (MR) studies to avoid inferential problems inherent to epidemi...

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Bibliographic Details
Main Authors: Raphael Hirtz, Christine Hars, Roaa Naaresh, Björn-Hergen Laabs, Jochen Antel, Corinna Grasemann, Anke Hinney, Johannes Hebebrand, Triinu Peters
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
depression
age at menarche
Mendelian randomization
BMI
puberty
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.918584/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.918584/full

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