The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration

The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to thousands copies in cells depending on cell metabolism and exposure to endogenous and/or environmental stressors. The coordination of mtDNA replication and transcription regulates the pace of mitochondrial biogenesis...

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Bibliographic Details
Main Authors: Anna Picca, Flora Guerra, Riccardo Calvani, Hélio José Coelho-Júnior, Christiaan Leeuwenburgh, Cecilia Bucci, Emanuele Marzetti
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Experimental Gerontology
Subjects:
Heteroplasmy
Mitochondrial biogenesis
mtDNA deletions
mtDNA mutations
Mitochondrial diseases
Mitochondrial quality
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556523001249

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http://www.sciencedirect.com/science/article/pii/S0531556523001249

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