Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein.

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein.

Combinations of monoclonal antibodies (mAbs) against different epitopes on the same antigen synergistically neutralize many viruses. However, there are limited studies assessing whether combining human mAbs against distinct regions of the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) enh...

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Bibliographic Details
Main Authors: Lawrence T Wang, Lais S Pereira, Patience K Kiyuka, Arne Schön, Neville K Kisalu, Rachel Vistein, Marlon Dillon, Brian G Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H Idris, Joseph R Francica, Robert A Seder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010133

Internet

https://doi.org/10.1371/journal.ppat.1010133

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