Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect

Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues using Af23 and NDGA as lea...

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Bibliographic Details
Main Authors: Qian Chen, Min Zhu, Jingwen Xie, Zhaojun Dong, Fatehi Khushafah, Di Yun, Weitao Fu, Ledan Wang, Tao Wei, Zhiguo Liu, Peihong Qiu, Jianzhang Wu, Wulan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
fibroblast growth factor receptor-1 inhibitor
synthesis
gastric cancer
chemosensitizing effect
nordihydroguaiaretic acid analogues
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.518068/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.518068/full

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