Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming

Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming

Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, the efficacy of CAR-T cell therapy against solid tumors has proven to be limited, primarily because the tumor-associated extracellular matrix (ECM) creates an intractable...

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Bibliographic Details
Main Authors: Ilya Klabukov, Alexander E. Kabakov, Anna Yakimova, Denis Baranovskii, Dmitry Sosin, Dmitry Atiakshin, Michael Ignatyuk, Elena Yatsenko, Victoria Rybachuk, Ekaterina Evstratova, Daria Eygel, Dmitry Kudlay, Vasiliy Stepanenko, Peter Shegay, Andrey D. Kaprin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Current Oncology
Subjects:
basement membrane
cancer
chimeric antigen receptor
CAR-T cell therapy
extracellular matrix
fibrosis
Online Access:https://www.mdpi.com/1718-7729/32/2/79

Internet

https://www.mdpi.com/1718-7729/32/2/79

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