Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2<i>H</i>-indazole Hybrids

Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2<i>H</i>-indazole Hybrids

Cancer is the second leading cause of death, after cardiovascular diseases. Different strategies have been developed to treat cancer; however, chemotherapy with cytotoxic agents is still the most widely used treatment approach. Nevertheless, drug resistance to available chemotherapeutic agents is st...

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Bibliographic Details
Main Authors: Jaime Pérez-Villanueva, Félix Matadamas-Martínez, Lilián Yépez-Mulia, Vadim Pérez-Koldenkova, Martha Leyte-Lugo, Karen Rodríguez-Villar, Francisco Cortés-Benítez, Ana Perla Macías-Jiménez, Ignacio González-Sánchez, Ariana Romero-Velásquez, Juan Francisco Palacios-Espinosa, Olivia Soria-Arteche
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
cancer
combretastatin A-4
cytotoxic activity
hybrid compounds
indazole
Online Access:https://www.mdpi.com/1424-8247/14/8/815

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https://www.mdpi.com/1424-8247/14/8/815

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