Staphylococcal Superantigen (TSST-1) Mutant Analysis Reveals that T Cell Activation Is Required for Biological Effects in the Rabbit Including the Cytokine Storm

Staphylococcal Superantigen (TSST-1) Mutant Analysis Reveals that T Cell Activation Is Required for Biological Effects in the Rabbit Including the Cytokine Storm

Staphylococcal superantigens (sAgs), such as toxic shock syndrome toxin 1 (TSST-1), induce massive cytokine production, which may result in toxic shock syndrome (TSS) and sepsis. Recently, we reported that in vitro studies in human peripheral blood mononuclear cells (PBMC) do not reflect the immunol...

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Bibliographic Details
Main Authors: Norbert Stich, Martina Waclavicek, Nina Model, Martha M. Eibl
Format: Article
Language:English
Published: MDPI AG 2010-09-01
Series:Toxins
Subjects:
sepsis
inflammation
T cell involvement
superantigens
endotoxin
Online Access:http://www.mdpi.com/2072-6651/2/9/2272/

Internet

http://www.mdpi.com/2072-6651/2/9/2272/

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