Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes

Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes

Abstract Background Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role in humans remains unknown. Methods We characterized the insulin regulation of THRSP in vivo in human adipose tissue biopsies and in vitro in S...

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Bibliographic Details
Main Authors: Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Molecular Medicine
Subjects:
Hexosylceramide
Insulin sensitivity
Oxidation
Thyroid hormone
Online Access:https://doi.org/10.1186/s10020-022-00496-3

Internet

https://doi.org/10.1186/s10020-022-00496-3

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