Ex vivo discovery of synergistic drug combinations for hematologic malignancies

Ex vivo discovery of synergistic drug combinations for hematologic malignancies

Combination therapies have improved outcomes for patients with acute myeloid leukemia (AML). However, these patients still have poor overall survival. Although many combination therapies are identified with high-throughput screening (HTS), these approaches are constrained to disease models that can...

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Bibliographic Details
Main Authors: Kamran A. Ali, Reecha D. Shah, Anukriti Dhar, Nina M. Myers, Cameron Nguyen, Arisa Paul, Jordan E. Mancuso, A. Scott Patterson, James P. Brody, Diane Heiser
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:SLAS Discovery
Subjects:
flow cytometry
Precision medicine
Drug discovery
Acute myeloid leukemia
Cancer
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555223000849

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http://www.sciencedirect.com/science/article/pii/S2472555223000849

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