Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

Recent data have revealed that soluble oligomeric amyloid-β peptide (Aβ) may be the proximate effectors of neuronal injuries and death in Alzheimer's disease (AD) by unknown mechanisms. Consistently, we recently demonstrated the critical role of a redox-sensitive cytosolic calcium-dependent pho...

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Bibliographic Details
Main Authors: Catherine Malaplate-Armand, Sabrina Florent-Béchard, Ihsen Youssef, Violette Koziel, Isabelle Sponne, Badreddine Kriem, Brigitte Leininger-Muller, Jean-Luc Olivier, Thierry Oster, Thierry Pillot
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Soluble amyloid-β oligomers
Cytosolic phospholipase A2
Sphingomyelinases and apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000519

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http://www.sciencedirect.com/science/article/pii/S0969996106000519

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