IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer

IGF2 Mediates Resistance to Isoform-Selective-Inhibitors of the PI3K in HPV Positive Head and Neck Cancer

Over 50% of human papilloma positive head-and-neck cancer (HNC<sup>HPV+</sup>) patients harbor genomic-alterations in <i>PIK3CA</i>, leading to hyperactivation of the phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K) pathway. Nevertheless, despite PI3K pathway activation...

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Bibliographic Details
Main Authors: Mai Badarni, Manu Prasad, Artemiy Golden, Baisali Bhattacharya, Liron Levin, Ksenia M. Yegodayev, Orr Dimitstein, Ben-Zion Joshua, Limor Cohen, Ekaterina Khrameeva, Dexin Kong, Angel Porgador, Alex Braiman, Jennifer R. Grandis, Barak Rotblat, Moshe Elkabets
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
head and neck cancer
HPV
IGF2
IGF1R
PI3K
therapy resistance
Online Access:https://www.mdpi.com/2072-6694/13/9/2250

Internet

https://www.mdpi.com/2072-6694/13/9/2250

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