Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model

Safety, Immunogenicity, and Protective Efficacy of an H5N1 Chimeric Cold-Adapted Attenuated Virus Vaccine in a Mouse Model

H5N1 influenza virus is a threat to public health worldwide. The virus can cause severe morbidity and mortality in humans. We constructed an H5N1 influenza candidate virus vaccine from the A/chicken/Guizhou/1153/2016 strain that was recommended by the World Health Organization. In this study, we des...

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Bibliographic Details
Main Authors: Weiyang Sun, Zhenfei Wang, Yue Sun, Dongxu Li, Menghan Zhu, Menglin Zhao, Yutian Wang, Jiaqi Xu, Yunyi Kong, Yuanguo Li, Na Feng, Tiecheng Wang, Yongkun Zhao, Songtao Yang, Yuwei Gao, Xianzhu Xia
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
H5N1 influenza virus
chimeric vaccine
mice
immune protection
Online Access:https://www.mdpi.com/1999-4915/13/12/2420

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https://www.mdpi.com/1999-4915/13/12/2420

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