Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes

Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes

ABSTRACT: Sustained lipolysis and insulin resistance increase the risk of metabolic dysfunction in dairy cows during the transition period. Proinflammatory cytokines are key regulators of adipose tissue metabolism in nonruminants, but biological functions of these molecules in ruminants are not well...

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Bibliographic Details
Main Authors: Xiliang Du, Mingchao Liu, Wenjun Tai, Hao Yu, Xue Hao, Juan J. Loor, Qianming Jiang, Zhiyuan Fang, Xinxing Gao, Minghe Fan, Wenwen Gao, Lin Lei, Yuxiang Song, Zhe Wang, Cai Zhang, Guowen Liu, Xinwei Li
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Dairy Science
Subjects:
proinflammatory cytokine
insulin resistance
lipid mobilization
adipocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0022030222004489

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http://www.sciencedirect.com/science/article/pii/S0022030222004489

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