Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

The initial excitement generated more than two decades ago by the discovery of drugs targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was short‐lived. However, the advent of the first clinical‐grade FASN inhibitor (TVB‐2640; denifanstat), which is currently being...

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Bibliographic Details
Main Authors: Javier A. Menendez, Elisabet Cuyàs, Jose Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop‐Hernández, Júlia López, Eila Serrano‐Hervás, Sílvia Osuna, Begoña Martin‐Castillo, Ruth Lupu
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
cell fate
ferroptosis
immunotherapy
metastasis
mitochondrial priming
molecular glues
Online Access:https://doi.org/10.1002/1878-0261.13582

Internet

https://doi.org/10.1002/1878-0261.13582

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