The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice

The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice

Oxygen depletion (O2) and a decrease in pH are initial pathophysiological events in stroke development, but secondary mechanisms of ischemic cell death are incompletely understood. By patch-clamp recordings of brain slice preparations we show that TASK1 and TASK3 channels are inhibited by pH-reducti...

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Bibliographic Details
Main Authors: Sven G. Meuth, Christoph Kleinschnitz, Tilman Broicher, Madeleine Austinat, Stefan Braeuninger, Stefan Bittner, Stephan Fischer, Douglas A. Bayliss, Thomas Budde, Guido Stoll, Heinz Wiendl
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neurobiology of Disease
Subjects:
Cerebral ischemia
Transient middle cerebral artery occlusion
Two-pore domain potassium channels
TASK channels
Thalamic neurons
TASK1−/− mice
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610800212X

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http://www.sciencedirect.com/science/article/pii/S096999610800212X

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