Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription

Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription

Summary: Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and FSS offers a crosstalk level to explain changes in SM...

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Bibliographic Details
Main Authors: Jerome Jatzlau, Paul-Lennard Mendez, Aybuge Altay, Lion Raaz, Yufei Zhang, Sophia Mähr, Akin Sesver, Maria Reichenbach, Stefan Mundlos, Martin Vingron, Petra Knaus
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014827

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http://www.sciencedirect.com/science/article/pii/S2589004223014827

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