Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment

Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyze post-translational deimination/citrullination of p...

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Bibliographic Details
Main Authors: Uchini S. Kosgodage, Paul Matewele, Giulia Mastroianni, Igor Kraev, Dominik Brotherton, Brigitte Awamaria, Anthony P. Nicholas, Sigrun Lange, Jameel M. Inal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
outer-membrane vesicles (OMVs)
peptidylarginine deiminase (PAD)
deimination/citrullination
antibiotic sensitivity
E. coli VCS257
S. aureus subsp. aureus Rosenbach
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00227/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00227/full

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