Long-term ingestion of β-lactoglobulin-bound AGEs induces colonic inflammation by modulating RAGE (TLR4)/MYD88/NF-κB signaling pathway and gut microbiota in mice

Long-term ingestion of β-lactoglobulin-bound AGEs induces colonic inflammation by modulating RAGE (TLR4)/MYD88/NF-κB signaling pathway and gut microbiota in mice

Thermally processed foods are rich in advanced glycation end products (AGEs). Our study aimed to investigate the effects of long-term ingestion of β-lactoglobulin bound AGEs (β-LG AGEs) on the gut microenvironment and underlying mechanisms. BALB/c mice were orally administered with β-LG AGEs (60/120...

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Bibliographic Details
Main Authors: Aiying Shi, Lu Dong, Yuekun Wu, Xiaoxia Liu, Wanhua Li, Jin Wang, Xuemeng Ji, Huan Lv, Yan Zhang, Shuo Wang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Functional Foods
Subjects:
Advanced glycation end products
Gut microbiota
Lipopolysaccharide
Tight junction protein
Short chain fatty acids
The receptor of advanced glycation end products (Toll-like receptor 4)/myeloid differentiation factor 88/ nuclear factor kappa-B signal pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623002906

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http://www.sciencedirect.com/science/article/pii/S1756464623002906

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