Sortilin‐Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain

Sortilin‐Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain

Abstract Neuropathic pain can occur during the prediabetic stage, even in the absence of hyperglycemia. The presence of prediabetic neuropathic pain (PDNP) poses challenges to the management of individuals with prediabetes. However, the mechanisms underlying this pain remain unclear. This study aims...

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Bibliographic Details
Main Authors: Wei Sun, Fan Yang, Yan Wang, Yan Yang, Rui Du, Xiao‐Liang Wang, Zhi‐Xin Luo, Jun‐Jie Wu, Jun Chen
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Advanced Science
Subjects:
dorsal root ganglion
hyperexcitability
prediabetic neuropathic pain
Sortilin
TREK1
TREK2
Online Access:https://doi.org/10.1002/advs.202310295

Internet

https://doi.org/10.1002/advs.202310295

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