Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells

Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells

The transcriptional regulator BRD4 has been shown to be important for the expression of several oncogenes including MYC. Inhibiting of BRD4 has broad antiproliferative activity in different cancer cell types. The small molecule JQ1 blocks the interaction of BRD4 with acetylated histones leading to t...

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Bibliographic Details
Main Authors: C. Otto, S. Schmidt, C. Kastner, S. Denk, J. Kettler, N. Müller, C.T. Germer, E. Wolf, P. Gallant, A. Wiegering
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558619303240

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http://www.sciencedirect.com/science/article/pii/S1476558619303240

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