Pathogenic variants carrier screening in New Brunswick: Acadians reveal high carrier frequency for multiple genetic disorders

Pathogenic variants carrier screening in New Brunswick: Acadians reveal high carrier frequency for multiple genetic disorders

Abstract Background Founder populations that have recently undergone important genetic bottlenecks such as French-Canadians and Ashkenazi Jews can harbor some pathogenic variants at a higher carrier rate than the general population, putting them at a higher risk for certain genetic diseases. In thes...

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Bibliographic Details
Main Authors: Philippe Pierre Robichaud, Eric P. Allain, Sarah Belbraouet, Claude Bhérer, Jean Mamelona, Jason Harquail, Stéphanie Crapoulet, Nicolas Crapoulet, Mathieu Bélanger, Mouna Ben Amor
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Medical Genomics
Subjects:
Acadians
Carrier screening
Founder population
Inherited disease
Online Access:https://doi.org/10.1186/s12920-022-01249-1

Internet

https://doi.org/10.1186/s12920-022-01249-1

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